Raymond-Roupen of Antioch (d.1219) was ruler of the principality of Antioch (a crusader state) between 1216 and 1219.
Raymond was the son of Raymond of Antioch, the eldest son of Bohemund III by his wife Alice of Armenia. Although the direct successor, he was overruled by his grandfather in favour of his paternal uncle Bohemund IV of Antioch, who inherited the principality in 1201. Raymond became prince of Antioch by the influence of his maternal uncle, Leo II, king of Armenia, who was in open conflict with Bohemund IV. His rule lasted only for three years, before Bohemund IV reconquered Antioch and regained control.