This is an alphabetical list of 44 baseball players from Panama which had played in Major League Baseball between 1955 and 2004.
- Ed Acosta
- Manuel Barrios
- Juan Berenguer
- Enrique Burgos
- Rod Carew
- Ossie Chavarría
- Bruce Chen
- Webbo Clarke
- Roger Deago
- Einar Díaz
- Mike Eden
- Gil Garrido
- Bill Haywood
- Tom Hughes
- Roberto Kelly
- Carlos Lee
- Allan Lewis
- Héctor López
- José Macías
- Carlos Maldonado
- Rafael Medina
- Ramiro Mendoza
- Orlando Miller
- Omar Moreno
- Julio Mosquera
- Ivan Murrell
- Sherman Obando
- Ben Oglivie
- Adolfo Phillips
- Bobby Prescott
- Fernando Ramsey
- Mariano Rivera
- Rubén Rivera
- Dave L. Roberts
- Humberto Robinson
- Olmedo Sáenz
- Chico Salmon
- Manny Sanguillen
- Pat Scantlebury
- Fernando Seguignol
- Rennie Stennett
- Rupe Toppin
- Ray Webster
- Julio Zuleta
