The name George Smith refers to a number of people:
- George Smith, former valet and footman to Charles, Prince of Wales
- George Smith, Victorian Assyriologist
- George Smith , founder of the Glenlivet Distillery in Ballindalloch, Scotland
- George Smith southeast London architect
- George Smith , Republican representative for Pennsylvania (1809-1812)
- George Smith , Republican representative for Minnesota (1913-1917)
- George Smith , manager of several football (soccer) clubs such as Portsmouth F.C.
- Sir George Smith , governor of Nyasaland (1913-1923)
- George Smith , finance administrator (1963-...)
- George Smith , born 1980, is a member of the Australian national rugby union team, the Wallabies.
- George Albert Smith , early British filmmaker
- George Albert Smith, president of the Church of Jesus Christ of Latter-day Saints
- George Charles Smith , chief minister of Norfolk Island
- George Edward Smith , mayor of Frederick, Maryland (1901-1910)
- George Harmonica Smith , harmonica player
- George I. Smith, premier of Nova Scotia (1967-1970)
- George Joseph Smith, the 'Brides in the Bath' murderer (1872-1915)
- George O. Smith, science fiction author
- George Otis Smith , director of U.S. Geological Survey, 1st chairman of Federal Power Commission
- George William Smith governor of Virginia (1811)
- George William Smith , (1874-1954) New Zealand track athlete and All Black rugby union player, also a founder of rugby league in Australasia.