The Gattilusio family was the ruling dynasty of the island of Lesbos from 1355 to 1462, when the last prince was strangled on the orders of Sultan Mehmed II. A junior branch of the family ruled Ainos until 1488. The family's origin was Genoese, the founder being a mercenary who assisted John V Palaeologus regain his throne and, as means of payment, received a princedom and the hand of the Emperor's sister, Maria Palaiologina .
Princes of Lesbos
- Francesco I of Lesbos (1355-1384)
- Francesco II of Lesbos (1384-1404)
- Jacopo of Lesbos (1404-1428)
- Dorino of Lesbos (1428-1455)
- Domenico of Lesbos (1455-1458)
- Niccolo of Lesbos (1458-1462)
Princes of Ainos
- Niccolo of Ainos (1355-1409), younger brother of Francesco I.
- Palamede of Ainos (1409-1455), younger brother of Jacopo and Dorino.
- Dorino of Ainos (1455-1488), son of Palamede, ceded his rights to his brother-in-law.
