Caithness and Sutherland was a constituency represented in the House of Commons of the Parliament of the United Kingdom. It consisted of the traditional counties of Caithness and Sutherland and became a part of the constituency of Caithness, Sutherland and Easter Ross.
Liberal candidate Archibald Sinclair was elected to represent Caithness and Sutherland in 1922 and held the seat for 23 years, until he lost it to Conservative candidate Eric Gander-Dower in the 1945 general election.